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Furthermore, its permeability and drug release capability can be enhanced by supplementing the liposome formation with distearoyl phosphocholine (DSPC) and hydrogenated soy phosphocholine (HSPC) [84]

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Recent data have demonstrated a stronger anti-nociceptive effect of norepinephrine than serotonin [94], and an increase in both norepinephrine and serotonin results in a greater analgesic effect than an increase in either one alone [95]